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These effects might be much more pronounced with concomitant usage of PERCOCET and CYP3A4 and CYP2D6 inhibitors, notably when an inhibitor is added following a stable dose of PERCOCET is attained [see WARNINGS].Mutagenesis The mixture of Oxycodone Hydrochloride and Acetaminophen hasn't been evaluated for mutagenicity. Oxycodone by yourself was nega